Seymour has heterochromia - her right eye is hazel, and her left is green. In 2007, she admitted to having undergone plastic surgery, including breast augmentation, and blepharoplasty.
Seymour has been married four times:
- 1971-1973: Michael Attenborough
- 1977-1978: Geoffrey Planer
- 1981-1992: David Flynn (with whom she had two children, Katherine Flynn, born January 7, 1982 and Sean, born 1986. Her daughter and stepdaughter, Jenni Flynn, appeared with her in the infomercial for cosmetics line, "Natural Advantage by Jane Seymour.")
- 1993 to present: James Keach (with whom she had twins, Johnny and Kris, born November 30, 1995, and named after family friends, Johnny Cash and Christopher Reeve)
Seymour dated musician Peter Cetera, former bass guitarist and lead singer of the rock band, Chicago during 1991. Her relationship with Cetera was publicized in a number of celebrity gossip magazines and supermarket tabloids of the time.
In 1984, Seymour bought, with then-husband, David Flynn, the Grade One listed St Catherine's Court for £350,000, located in the village of St Catherine, near Bath, Somerset. After spending £3 million on refurbishments, she spent her summers at the house, and her winters in Malibu. After her divorce from Flynn, and marriage to Keach, she spent more time in the US, and made little use of the house, so she began to rent it out. In 1996, during that season's filming for
Dr Quinn, Medicine Woman, she rented it, to English rock group, Radiohead, who recorded their album,
OK Computer, at the house. Another famous group that occupied the home are The Cure. In May 2007, she was granted a 24-hour alcohol and entertainment licence, under new UK regulations. However, this caused much disturbance with neighbours, who claimed the access lane was too narrow, and the noise too excessive. Seymour won the court battle, but sold the house in November 2007.
Seymour was named an Officer of the Order of the British Empire by Queen Elizabeth II, in 2000.
Seymour is a patron of Meningitis UK.
Seymour is a celebrity ambassador, for the non-profit organisation, Childhelp. She regularly makes appearances at fund raisers, and events for the child abuse prevention, and treatment organisation, and is an ardent supporter. In 2007, she sponsored a children's Art Pillow contest, as part of the Jane Seymour Collection. 100% of the proceeds went to Childhelp.
An allergic reaction to antibiotic medicine on a film shoot in Spain almost killed her, and the scrape with death profoundly changed her whole outlook on life. Seymour explains: "I saw the white light and I saw, from the corner of the room, them trying to resuscitate me, and I saw a syringe, with blood in it. It did change my whole life, because, when you die, I realised, you take nothing with you, except for what you've done."
On December 2, 2008, she was honoured by the Christopher and Dana Reeve Foundation, in a ceremony in Los Angeles, for her work with people with disabilities.
In late 2009, furniture supplier AICO and founder/CEO Michael Amini announced that they will collaborate with Jane Seymour to co-brand a new line of fine furniture. The line of furniture was unveiled in February 2010 and featured three collections consisting of a traditional collection, a casual European collection, and a Hollywood glamour collection.
She currently resides in Malibu, California, with her husband, and twin sons.